Liquid State Intelligence for Antibody Behaviour
Behaviour determines whether even the best therapeutic candidates survive development. It isn't a fixed property - it's the dynamic response of a molecule under real-world stress, and it matters at every stage, from manufacturing to patient.
Apoha resolves that behaviour directly, capturing a molecule's full behavioural state in a single measurement. We call this new data class States - the third fundamental layer of molecular science, alongside sequence and structure.
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Apoha is your partner at every stage of drug development.
Cut inevitable failures at hit-ID and lead selection
Run a VIBE check at hit-ID and cut your worst candidates before they cost you. When the VIBE check flags an antibody, it's bad>90% of the time — with single-amino-acid resolution from just 10µg of material. Screen wider. Waste less.
See the full picture of developability — and know why candidates fail
Apoha doesn't just flag bad antibodies. It tells you why they're bad — breaking down developability across the molecular properties that matter: hydrophobicity, conformational flexibility, surface charge, and more. One measurement. The full picture.
Optimize formulation with confidence
Take your shortlist deeper. Run pH sweeps, concentration sweeps, and buffer comparisons to understand how each candidate behaves under the conditions that matter. Then close the loop: use sequence-level insights to engineer better molecules, express, re-test, and iterate — lab-in-the-loop, powered by Apoha.
Monitor protein quality during bioprocessing
Bioprocessing today tracks cell health — oxygen, glucose, pH — but not the protein itself. A batch can run for weeks before a quality failure is discovered, and by then it's lost. Apoha is building deployable hardware to monitor protein quality on-site throughout the run, so you catch issues as they happen.
Predict how sequence changes impact developability
Proprietary thermodynamic data generated by the Apoha platform powers smarter, better-designed molecules — moving from flagging bad candidates to engineering better ones from the start.
The Science that Powers Apoha
